Bruker today announced the launch of FluidFM® on the BioScope Resolve® AFM. For the first time, cell biology researchers can combine the femtoliters-scale fluid control and injection capability of Cytosurge’s FluidFM technology with the force control, resolution, and speed that is only available with Bruker’s PeakForce Tapping® technology. The combined product opens the door to a whole range of novel single-cell investigations, including colloidal probe spectroscopy, single-cell injection, and single-bacteria adhesion studies.
BioScope Resolve comes with PeakForce Quantitative Nanomechanics (PeakForce QNM®), which uniquely enables mapping of receptors on live cells. With the addition of FluidFM, researchers can now routinely pick up and drop off colloids and thereby effectively change tips whenever needed in PeakForce QNM enabled force spectroscopy experiments. They can also inject or manipulate cells, and then track changes to mechanical properties on dozens of cells using the system’s new Advanced Correlation Stage, which extends BioAFM operation to the millimeters range. Moreover, researchers can execute single bacteria adhesion studies that combine FluidFM with BioScope Resolve’s optical synchronization to correlate adhesion and confocal fluorescence data in investigations of biofilms and pathogenic pathways.
“Manipulating cells, and injecting biomolecules into cells while sensing piconewton forces, and imaging at the nanometer scale, are AFM capabilities that enable fundamentally new correlative information,” said David V. Rossi, Executive Vice President and General Manager of Bruker's AFM Business. “Partnering with Cytosurge to integrate FluidFM with BioScope Resolve and PeakForce Tapping technology fits perfectly with our strategy to take BioAFM experiments beyond imaging, from mechanobiology and drug delivery to the probing of biochemical interactions.”
About BioScope Resolve
Specifically designed for highest resolution on an inverted optical microscope, BioScope Resolve (bruker.com/bioafm) is the only AFM to image individual microvilli on live cells. Its exclusive PeakForce QNM and FASTForce Volume™ techniques deliver the highest resolution and fastest force mapping capabilities possible with an AFM, with the widest range of force distance ramp rates. In addition, the system offers complete synchronization of AFM imaging and force spectroscopy with optical microscopy techniques over the entire stage range, enabling new kinds of experiments with its advanced correlation stage. BioScope Resolve provides the most complete range of capabilities for cell mechanics and molecular force spectroscopy, and is available with a full array of accessories, including temperature and environmental control for live-cell imaging.
About Cytosurge AG
Founded in 2009, Cytosurge AG (cytosurge.com) successfully develops, manufactures and distributes cutting-edge and unique nanotechnology instruments based on its patented FluidFM technology. Cytosurge is focusing its activities into three distinct customer-focused business units: AFM SOLUTIONS, CELL & BIOSCIENCE and 3DPRINTING, each perfectly adapted to its specific target market. Whether via the FluidFM ADD-ON, a powerful upgrade solution for you AFM; the FluidFM BOT, a fully integrated system for injection into single cells; or via the award-winning FluidFM µ3DPRINTER, a standalone system for 3D metal printing at micrometer scale, Cytosurge provides leading-edge tools and processes to those who need or want to go beyond current technological boundaries.
About Bruker Corporation
For more than 55 years, Bruker (bruker.com) has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, phenomics and proteomics research, microbiology and molecular pathology research.