Imec, the world-leading research and innovation hub in nanoelectronics and digital technologies, released and is making available its state-of-the-art high-density neural probe, Neuropixels, to the global neuroscience research community. With almost a thousand electrodes, and 384 recording channels on a single shank, the Neuropixels probe provides an unprecedented resolution for mapping brain activity. The probes are designed and fabricated on imec’s advanced silicon platform.
Five years ago, in June 2013, the Howard Hughes Medical Institute’s (HHMI) Janelia Research Campus initiated an international project with imec, the Wellcome Trust, the Gatsby Charitable Foundation and the Allen Institute for Brain Science to develop a next generation tool for electrophysiology. The result of this collaboration was the Neuropixels probes, which were designed, developed and fabricated by imec in collaboration with HHMI Janelia Research Campus, Allen Institute for Brain Science, and University College of London. The performance of the Neuropixels probes and their potential for transformational neuroscience experiments was described in a November 9, 2017 paper published in Nature.
Starting October 31, 2018, imec is making the Neuropixels probes available to the global Neuroscience research community. Information on accessing and using the Neuropixels probes is available on the Neuropixels website at neuropixels.org
“The Neuropixels probe is the most advanced neural electrophysiology probe to date, thanks to the power of integration of advanced CMOS chip technology. I sincerely hope that the Neuropixels probe will revolutionize the way neuroscience research is performed and propel our understanding of complex brain processes and diseases forward. In addition, I hope this is the beginning of a journey of bringing together like minded funders of Neuroscience Research Tools and imec, such that there is continuous funding to provide path breaking tools to the Neuroscience community at a regular cadence leveraging the strength of Moore’s Law” said Barun Dutta, chief scientist at imec, who has led the imec Neuropixels program since inception.
Tim Harris, senior fellow of HHMI: “Neuropixels was made possible by the generosity of our funders, HHMI Janelia, Allen, Gatsby and Wellcome, the world class engineering design and fabrication at imec, and the tireless work of the consortium to agree and test a single design. We hope this can be a technology development example for other life science research tools.”
“In the race between optical and electric methods of recording large-scale cellular activity, imec’s Neuropixels just delivered the next great leap forward reliably recording spikes from hundreds of neurons simultaneously with sub-millisecond resolution in a small, convenient and inexpensive package,” said Christof Koch, Ph.D., president and chief scientist at the Allen Institute for Brain Science.
Professor John O’Keefe, neurophysiologist at University College London and Fellow of the Royal Society: “Systems neuroscience is undergoing a seismic revolution in which we are getting access to technical devices which will enable us to record from hundreds and thousands of neurons at the same time in behaving animals. Most of us believe that the important computations of the brain such as those involved in cognition, emotions, decisions, and actions are carried out by networks of neurons and that we will only begin to understand how the brain works when we can record the activity of substantial parts of these networks. The Neuropixels probe is a giant step in this direction and will enable us to probe these circuits with a temporal resolution that has not been possible previously. We salute the technical skills of the imec team and the foresight of our funders and institutions in supporting and executing this state-of-the-art neural engineering project.”
Imec (imec-int.com) is the world-leading research and innovation hub in nanoelectronics and digital technologies. The combination of our widely acclaimed leadership in microchip technology and profound software and ICT expertise is what makes us unique. By leveraging our world-class infrastructure and local and global ecosystem of partners across a multitude of industries, we create groundbreaking innovation in application domains such as healthcare, smart cities and mobility, logistics and manufacturing, energy and education.
As a trusted partner for companies, start-ups and universities we bring together more than 4,000 brilliant minds from over 85 nationalities. Imec is headquartered in Leuven, Belgium and has distributed R&D groups at a number of Flemish universities, in the Netherlands, Taiwan, USA, China, and offices in India and Japan. In 2017, imec's revenue (P&L) totaled 546 million euro.
Imec is a registered trademark for the activities of IMEC International (a legal entity set up under Belgian law as a "stichting van openbaar nut”), imec Belgium (IMEC vzw supported by the Flemish Government), imec the Netherlands (Stichting IMEC Nederland, part of Holst Centre which is supported by the Dutch Government), imec Taiwan (IMEC Taiwan Co.) and imec China (IMEC Microelectronics (Shanghai) Co. Ltd.) and imec India (Imec India Private Limited), imec Florida (IMEC USA nanoelectronics design center).
About Howard Hughes Medical Institute
The Allen Institute for Brain Science is a division of the Allen Institute (alleninstitute.org), an independent, 501©(3) nonprofit medical research organization, and is dedicated to accelerating the understanding of how the human brain works in health and disease. Using a big science approach, the Allen Institute generates useful public resources used by researchers and organizations around the globe, drives technological and analytical advances, and discovers fundamental brain properties through integration of experiments, modeling and theory. Launched in 2003 with a seed contribution from founder and philanthropist Paul G. Allen, the Allen Institute is supported by a diversity of government, foundation and private funds to enable its projects.